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Synlett
DOI: 10.1055/a-2765-9249
Letter

P(NMe₂)₃-Mediated Domino Cyclization/Functionalization of Dicyanoalkenes

Authors

  • Min Xiang

    1   Department of Chemistry and Chemical Engineering, Zunyi Normal University, Zunyi, China

  • Jia-Xi Min

    1   Department of Chemistry and Chemical Engineering, Zunyi Normal University, Zunyi, China

  • Guang-Wei Wang

    1   Department of Chemistry and Chemical Engineering, Zunyi Normal University, Zunyi, China

  • yunqing Jia 

    2   College of Chemistry and Chemical Engineering, Zunyi Normal University, Zunyi, China

  • Li-Wen Shen

    1   Department of Chemistry and Chemical Engineering, Zunyi Normal University, Zunyi, China

Supported by: Start-up Fund of Zunyi Normal College BS[2022]4, BS[2022]5
Supported by: Natural Science Research Project of Guizhou Department of Education [2024]200
Supported by: Science and Technology Plan Project of Guizhou ZK[2024]673
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A P(NMe₂)₃-mediated domino reaction between dicyanoalkenes and benzoylformates has been developed. By switching between isatin-and tetralone-derived dicyanoalkenes, the protocol divergently furnishes either spiro-cyclopropyl oxindoles or α-functionalized dicyanoalkenes in up to 99 % yield under mild conditions. Gram-scale experiments and broad substrate scope highlight the synthetic utility of the transformation.



Publication History

Received: 10 November 2025

Accepted after revision: 05 December 2025

Accepted Manuscript online:
05 December 2025

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